Quinacrine (mepacrine) action at frog end-plate.
نویسندگان
چکیده
منابع مشابه
Protons resolve dual effects of calcium on miniature end-plate potential frequency at frog neuromuscular junctions
Inhibition of transmitter release by protons (H+) was studied at the frog neuromuscular junction at various extracellular concentrations of calcium ([Ca++]o) and potassium ([K+]o) by recording miniature end-plate potential (MEPP) frequency with the intracellular microelectrode. H+ decreased K+ -stimulated MEPP frequency. A double logarithmic graph of MEPP frequency at 7.5 mM K+ vs. [H+]o yielde...
متن کاملVoltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.
1. Acetylcholine produced end-plate current (e.p.c.) noise is shown to be the results of statistical fluctuations in the ionic conductance of voltage clamped end-plates of Rana pipiens.2. These e.p.c. fluctuations are characterized by their e.p.c. spectra which conform to a relation predicted from a simple model of end-plate channel gating behaviour.3. The rate constant of channel closing alpha...
متن کاملFast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate.
The fine structure of ion-channel activations by junctional nicotinic receptors in adult frog muscle fibres has been investigated. The agonists used were acetylcholine (ACh), carbachol (CCh), suberyldicholine (SubCh) and decan-1,10-dicarboxylic acid dicholine ester (DecCh). Individual activations (bursts) were interrupted by short closed periods; the distribution of their durations showed a maj...
متن کاملEffects of Cesium Ions on the Frequency of Miniature End Potentials at the Frog Neuromuscular Junction -Plate
The effects of Cs ions on the frequency of miniature end-plate potentials (MEPPs) were. investigated at the frog neuromuscular junction. The frequency of MEPPs increased gradually with time, after a delay, when part of the NaCI in normal Ringer's solution was replaced isotonically with CsCI. The delay was greatly prolonged and the rate of increase in MEPP frequency slowed when a low concentrati...
متن کاملOn the mechanism of calcium actions on the acetylcholine receptor-channel complex at the frog end-plate membrane.
The mechanism of depressant effects of Ca2+ on the acetylcholine (ACh)-activated ion channel conductance was studied in frog muscle fibers. Increasing the extracellular Ca2+ ( (Ca2+)o) suppressed the increase in the end-plate conductance induced by iontophoretic application of ACh and shifted the reversal potential for a neurally-induced end-plate current to a more negative value. The single ch...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1980
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1980.sp013396